The ongoing opioid overdose epidemic has contributed to unprecedented and unnecessary deaths, with an estimated 100,306 deaths from prescription and illegal opioid use in the United States in the 12 months before April 2021 [1] and 5360 deaths in Canada in the first 9 months of 2022 [2]. For many patients with an opioid use disorder, the perioperative period represents the source of initial exposure (>6% compared to 0.4% in a control cohort without surgery in the United States) [3]. Hence, effective postoperative pain management, with less reliance on the prescription of opioids, could be a valuable mechanism to reduce the development of subsequent opioid use disorder. Postsurgical opioids are most frequently prescribed by the surgeon and followed up by the patient’s primary care physician [4]. Anesthesiologists are uniquely positioned to manage acute postoperative pain effectively with multimodal analgesia to decrease perioperative opioid exposure and prevent subsequent persistent opioid use [3].

Perioperative health care is being optimized through enhanced recovery after surgery (ERAS) pathways [4-6], multimodal analgesic plans [5,7,8], and regional anesthesia techniques [9]. Further opportunities to improve postsurgical pain trajectories are offered by prehabilitation programs [10-12], our developing understanding of the risks of persistent postsurgical pain [13-17], and the feasibility of accessing and analyzing large volumes of data. A critical step is identifying patients at high risk of significant postsurgical pain and long-term opioid use.

The Perioperative Opioid Quality Improvement (POQI) program was designed to address the ongoing opioid use epidemic in British Columbia, where opioid use disorder continues to be one of the most pressing public health concerns. Recent studies have highlighted the scale of the local opioid problem and highlighted the case for addressing opioid risk during routine clinical care, including surgery: 12% of our population received an opioid prescription in 2017, with the number of people who receive a high dose (>90 morphine milligram equivalents [MME]/day) increasing during the period from 2013 to 2017 [18]; patients with opioid overdose have often had previous clinical encounters for pain (50%) and surgery (5%) [19].

The POQI program was funded in 2019 by DIGITAL, Canada’s Global Innovation Cluster for digital technologies, as a consortium between digital health companies, health care organizations, and university partners. It aimed to develop and implement a postsurgical pain risk stratification algorithm by integrating several commercially available digital health solutions into a combined POQI digital health platform for prehabilitation and postsurgical care planning. The COVID-19 pandemic adversely impacted the ability to engage clinicians and patients in co-designing and testing the solution iteratively. Hence, the project faced significant delays, and the scope of the POQI platform development was reduced. Specifically, planned features for 2-way communication and personalization of educational information for patients were not included in the prototype tested in this study.

The specific objectives of the pilot deployment of the POQI platform were to assess (1) the screening performance of the risk stratification algorithm to facilitate subsequent risk score optimization and (2) the use, utility, and perceived benefit of the POQI platform among end users (clinicians and patients).

The study involved the design, implementation, and pilot evaluation of the POQI digital health platform at Providence Health Care’s (PHC’s) St. Paul’s Hospital in Vancouver, British Columbia, Canada. The target users were clinicians and patients. The patient population for pilot-testing had undergone a designated set of colorectal surgeries; this population was selected because the colorectal surgical clinic was an early adopter of an electronic health history questionnaire (HHQ) upon which the platform expanded. As a result of this initiative, the Department of Anesthesiology and Pain Medicine at PHC established a new Transitional Pain Clinic for patients at risk of persistent postoperative pain or opioid use after surgery. It held weekly clinics during the study period and continued to serve St. Paul’s Hospital patients after the study concluded.

The POQI platform incorporated an algorithm [20] that classified patients as low risk or high risk for persistent postsurgical pain and long-term opioid use. Clinicians used this classification to assign patients to low-risk or high-risk pathways for personalized prehabilitation, patient education, and care planning. Specifically, patients were told that there were resources that they could use to learn about pain and nonpharmacologic strategies for pain management and that they could keep track of their medication use and pain scores over time in the system. The performance of this risk stratification was evaluated based on observed postoperative inpatient opioid use. The clinician and patient user experiences were evaluated using mixed methods.

The University of British Columbia PHC Research Ethics Board determined this work to be a quality improvement project (reviewed on October 13, 2020), for which they do not require ethical review under Article 2.5 of the Canadian Tri-Council Policy Statement [21]. Hence, this project was run as a quality improvement pilot project governed by Privacy Impact Assessment and Security Threat and Risk Assessment. This manuscript adheres to the SQUIRE 2.0 (Standards for Quality Improvement Reporting Excellence) reporting guidelines [22].

Development of the POQI platform combined existing technologies from 3 industry partners (Figure 1): a preoperative survey and POQI platform for low-risk patients (POQI-L), supplied by Thrive Health; a POQI platform for high-risk patients (POQI-H), supplied by Careteam Technologies; and a data broker, supplied by Excelar Technologies (also incorporating Xerus Medical from 2021). Additional components were identified and developed based on the needs of the clinical implementation partners (the anesthesiologists and perioperative care team at St. Paul’s Hospital). The platform’s original scope of development work was scaled back due to resource and time constraints during the COVID-19 pandemic. The resultant POQI platform used in this study should be considered an initial prototype. Original development plans included (1) additional iterations of user testing and design refinement; (2) additional features, such as 2-way communication between patients and clinicians; and (3) personalization of educational materials to meet patients’ needs optimally.

The prototype POQI platform allowed for the collection of patient-specific data, including a presurgical HHQ (questions selected as risk factors for modeling are presented in Multimedia Appendix 1) and patient-reported outcome measures (PROMs) at baseline. Furthermore, data were collected postoperatively using quality of recovery-15 (QoR-15) questionnaires [23] and additional PROM surveys to collect self-reported medication use and pain (scores). The platform was linked to an automated export from the Cerner electronic medical record (EMR) system (Cerner Corp), which allowed for collecting surgery details and oral and intravenous opioid use data from inpatient medication administration records.

Initial HHQ data were used to stratify patients for risk of persistent postsurgical pain and opioid use, using a previously developed risk score, which was based on the data collected from 122 patients who underwent colorectal surgery; 22 (18%) of them had high postoperative opioid use, which was strongly associated with a history of chronic pain, substance use disorder, and open surgery [20]. Patients were categorized into high-risk and low-risk groups using a point-based prediction model that considered 11 risk factors with different weights [20]: substance use disorder (risk score weight=5); current prescription of opioid (risk score weight=5), benzodiazepine (risk score weight=4), or antidepressant (risk score weight=4); recreational drug use (risk score weight=4); history of chronic pain (risk score weight=4), anxiety or panic attacks (risk score weight=2), depression (risk score weight=2), or poorly controlled pain after surgery (risk score weight=2); female sex (risk score weight=2); and age <40 years (risk score weight=1; refer to relevant HHQ questions in Multimedia Appendix 1). The algorithm flagged a patient as high risk if the risk score was >7 out of 35, after which a clinician manually onboarded the patient to the POQI-H platform or confirmed that they should remain on the POQI-L platform. The clinician could override the algorithm’s proposed risk label if they deemed it clinically appropriate. In addition, clinicians could use their clinical judgment to manually onboard patients directly to POQI-H after the St. Paul’s Hospital Transitional Pain Clinic consultation, even when no electronic HHQ data were available.

High-risk patients were given a care plan that provided them with education about pain and opioid management and prompted them to record their medication use and pain scores (refer to the Study Design and Approval section for details). Some high-risk patients were also seen preoperatively in St. Paul’s Hospital Transitional Pain Clinic for prehabilitation, education, and pain management planning when the responsible clinician deemed it appropriate. Postoperatively, high-risk patients were flagged by St. Paul’s Hospital Transitional Pain Clinic providers for closer follow-up by the Acute Pain Service clinicians in the hospital.

Regardless of the risk categorization, patients who used a significant quantity of opioids postoperatively (>90 MME) were also followed by St. Paul’s Hospital Transitional Pain Service for optimization of their postdischarge pain management and opioid weaning; 90 MME was chosen as the threshold for referral, as it is recommended in the 2017 Canadian Guideline for Opioids for Chronic Non-Cancer Pain that patients using >90 MME per day be weaned to the lowest effective dose, potentially including discontinuation [24].

Pilot use of the POQI platform was initiated at St. Paul’s Hospital in December 2021 and formally adopted on January 1, 2022. The target population for pilot-testing included patients undergoing a designated set of colorectal surgeries during the active enrollment period (Multimedia Appendix 2) and excluded patients who underwent screening and minimally invasive diagnostic procedures such as endoscopies. Patients who had a surgery that was not included in the designated set or had undergone procedures with a surgical time of <20 minutes were excluded. Furthermore, patients who underwent surgery before January 1, 2022, were excluded, as the complete POQI platform implementation was not available for clinical use until then. Only the surgical encounter closest to the most recently recorded HHQ was considered when patients had multiple procedures. Eligible patients were enrolled for the pilot through routine clinical care by the medical office assistant in surgical clinics (Figure 2). Postoperative data collection continued for up to 120 days after surgery, with surveys potentially completed on postoperative days 7, 14, 30, 60, 90, and 120.

The patient-specific data, including preoperative baseline HHQ, QoR-15 questionnaires, and PROM surveys, were fed directly to the data broker from the respective POQI-L or POQI-H platforms. The surgery details and opioid use data from the medication administration record were extracted from the EMR. These data were made available in a data lake by the Excelar data broker for analysis. The unifying variables used to link the multiple platforms were the patient’s personal health number and the ThriveID, assigned at the initial onboarding for HHQ completion. Data for this evaluation were aggregated and deidentified (Figure 2). The deidentified data sets were then exported to the research team for analysis.

The available data were summarized for high- and low-risk patients, including patient count, age distribution, surgical wait time (time to surgery after referral for surgical care), procedure duration, length of hospital stay, the identified risk factors from the HHQ (refer to The POQI Digital Health Platform section), preoperative and postoperative QoR-15 scores, the proportion of the population that completed the QoR-15, length of follow-up, the number of emergent readmissions, in-hospital opioid use in MME/day, and most prevalent surgeries. Frequency data are reported as n/N (%); the denominator N changes due to data linking issues and loss of follow-up during the study period.

Due to the small sample size, data for low- and high-risk groups were compared using nonparametric statistical tests: the Fisher exact test for counts and the Mann-Whitney U test for continuous data. A logistic regression of all risk factors for high in-hospital opioid use was performed to generate adjusted odds ratios (ORs), reported with 95% CIs. Analyses were performed using Python (version 3.10; Python Software Foundation): Pandas (version 1.5.0; Wes McKinney), SciPy (version 1.9.3; Enthought), and NumPy (version 1.23.3) were used for data cleaning, processing, and analysis; Matplotlib (version 3.6.0) was used to generate plots; and Openpyxl (version 3.0.10) was used to create analysis reports. R software (version 4.2.2; The R Foundation) was used for statistical comparisons.

The accuracy of the risk stratification was assessed to determine if the algorithm was sensitive enough to categorize patients based on their health history. This was achieved by constructing confusion matrices using the high- and low-risk labels generated by the risk prediction algorithm (using HHQ data, not POQI-L or POQI-H enrollment labels) and the outcome, that is, high (>90 MME/day) and low (≤90 MME/day) opioid use. These data were used to estimate sensitivity, specificity, false negative rate, false positive rate, and positive and negative likelihoods.

Scatter with line (median) plots and box plots were created to determine the trend of opioid use by patients on postoperative days 0 to 10 and to compare the trend between low- and high-risk patients.

A total of 276 eligible patients were admitted for one of the colorectal procedures selected for inclusion in the study at St. Paul’s Hospital between January 01, 2022, and September 30, 2022, and completed the HHQ before surgery (Figure 3). The denominators vary in the result tables due to the selective completion of surveys and the availability of linked data.

Of the 276 patients, the risk stratification algorithm identified 203 (73.6%) patients as low risk and 73 (26.4%) as high risk. The most common surgeries for low-risk patients were laparoscopic resection of the anterior colon, transanal resection of a rectal lesion by assisted microsurgery, and laparoscopic resection of the bowel. The most common surgeries for high-risk patients were laparoscopic resection of the anterior colon, laparoscopic resection of the bowel, and lysis of adhesions.

The most substantial differences in risk factors between the high-risk and low-risk groups were history of depression (OR 29.4, 95% CI 9.2-125; risk score weight=2), antidepressant prescription (OR 23.4, 95% CI 7.9-85.2; risk score weight=4), current opioid prescription (OR 20.4, 95% CI 4.2-196.4; risk score weight=5), and history of chronic pain (OR 19.4, 95% CI 6.9-63.3; risk score weight=4; Table 1).

High-risk patients were younger than low-risk patients (age: median 53, IQR years, vs median 59, IQR years, median difference [MD] 5 years, 95% CI 1-9; P=.02) and were more often female (45/73, 62%, vs 80/203, 39.4%; OR 2.5, 95% CI 1.4-4.5; P=.002; Table 2). Furthermore, high-risk patients reported lower baseline (preoperative) QoR scores (median 122, IQR 91-136, vs median 131, IQR 116-140, MD 12, 95% CI 2-23; P=.02).

Overall inpatient opioid use was not significantly different between the 2 risk groups, with a median of 20 IQR (10-45) MME/day in low-risk cases versus a median of 25 IQR (10-50) MME/day in high-risk cases (MD –2, 95% CI –5 to 0; P=.10; Table 3). Similarly, no significant difference was observed in opioid use across the recovery profile of low- versus high-risk patients over the first 10 postoperative days (Figure 4). Our risk factors were not strong predictors for high MME/day: none of the ORs from logistic regression were significant (ie, 95% CI range included 1 for all predictors), which differs from our original model building cohort [20] (Table 4, right column).

Readmissions and other postoperative outcomes did not differ between high- and low-risk groups, although the overall median postoperative QoR-15 score was higher in the low-risk group than in the high-risk group (MD 11, 95% CI 4-19; P=.002; Table 5).

In terms of performance, with an incidence of opioid use of >90 MME/day as the primary outcome, the pilot risk stratification algorithm was reasonably specific (true negative rate=144/200, 72%) but not sensitive (true positive rate=10/31, 32%). These equate to a high false negative rate of 68% (21/31), with a false positive rate of 28% (56/200), a positive likelihood of 1.15, and a negative likelihood of 0.94.

Data are available for 214 (77.5%) of the 276 patients who completed the HHQ and were risk stratified by the POQI platform (low-risk patients: 161/203, 79.3%; high-risk patients: 53/73, 73%). Of the 276 patients, 85 (30.8%) completed any postoperative QoR-15 questionnaire (low-risk patients: 59/203, 29.1%; high-risk patients: 26/73, 36%). Similarly, 31 (15.3%) of the 203 low-risk patients and 3 (4.1%) of the 73 high-risk patients reported any postoperative opioid use (Table 6).

We conducted feedback interviews with 3 (15%) patients (2 POQI-L users and 1 POQI-H user) of the 20 invited patients; most patients (17/20, 85%) approached declined to participate in this portion of the study. We interviewed all 4 clinicians (anesthesiologists and nurses who used both platforms) involved in the platform deployment in St. Paul’s Hospital Transitional Pain Clinic.

Patients recognized that the POQI-L had improved their health care experience by making them mindful of their behavior, such as “stating how I was feeling, anxiety about things, etc,” which gave them “a sense of agency” over their care. It also provided a sense of reassurance that the health care team was continually monitoring their health status after they returned home following hospital discharge. Similarly, the POQI-H user believed there was a potential benefit:

However, they did not feel that the potential had been met with the current version.

The clinical users perceived minimal benefits of the POQI-H, such as improving their workflows and allowing them to manage their patients better. However, they recognized potential patient benefits, including access to educational information:

The clinical users identified benefits of the POQI-L, which administered the HHQ to all patients as a screening and triage tool: clinicians reported that it was helpful to display the pain risk score and “to see whether they’re a high or low risk as a quick way to screen patients.” Integrating patient information in a single document was also helpful:

Patients experienced issues using both platforms, although this may have resulted from poor communication of the purpose of the application and potential benefits for them:

Furthermore, there was a lack of clarity in instructions for using both platforms; for example, the POQI-L users expressed frustration about redundant emails or SMS text messages, which were unclear about “what was supposed to be completed and when,” and the POQI-H user said as follows:

Furthermore, the 2 POQI-L participants were unaware of their postoperative risk score and its details and viewed this as a missed opportunity to benefit from understanding their personalized risk for significant postsurgical pain.

Similarly, usability issues during the initial deployment contributed to attrition among clinical users; for example, 1 clinician admitted that they had not signed patients up on the POQI-H for 4 months, as they did not find it easy to use, were not satisfied with the functionality, and could not quickly locate necessary information; another clinician had “stopped using [POQI-L] as a method to look up patients and filter them out to see who should be put on [POQI-H].” The clinicians who had used both platforms expressed concerns with quality assurance and usability:

I think both platforms have much potential when they’re working... [but]there have been many [issues] to deal with in the development of the programs, which have been both challenging and frustrating.

Both patients and clinicians expressed a desire for greater platform integration. One patient stated as follows:

Clinicians indicated that there should be a single platform with a unified vision; for example, a clinician stated as follows:

A pragmatic risk prediction algorithm was used to categorize 276 patients who underwent colorectal surgery into high-risk or low-risk groups for significant postoperative pain. The algorithm’s performance was evaluated using a primary outcome threshold of >90 MME/day during in-hospital recovery: it was found to be reasonably specific (true negative rate=14/200, 72%) but not sensitive (true positive rate=10/31, 32%). Furthermore, the risk categorization was used to drive dedicated preoperative and postoperative patient surveys using the high-risk (POQI-H) or low-risk (POQI-L) platforms. Preoperative surveys, including HHQ, were completed by 214 (77.5%) of the 276 patients, but there was a significant loss to follow-up with postoperative surveys, including QoR-15, completed by only 85 (39.7%) of the 214 patients. Qualitative feedback from clinician and patient users indicated shortcomings in the design and implementation of the patient- and clinician-facing components of the POQI platform.

The motivation was that POQI would establish a platform to support personalized multimodal pain management techniques and patient preparation or education to reduce reliance on opioids (both in-hospital and postdischarge opioid use) during recovery from surgery. Identifying those at most significant risk of postoperative pain and providing tailored care plans based on their risk levels may help reduce initial opioid consumption. A recent systematic review suggested that a higher risk of developing persistent postsurgical pain is associated with younger age, female sex, and preoperative pain [25], which are consistent with the characteristics observed in the patients classified as high risk by our algorithm (Table 2). Furthermore, a recent multicenter study in the United States identified preoperative opioid use as the most significant predictor of prolonged opioid use after surgery [26]. Again, this factor was a significant distinguishing characteristic of our high-risk patients, along with a history of depression, antidepressant use, and chronic pain (Table 2).

Virtual care solutions for patients in the postsurgical period, including web-based tools and mobile apps, can support tracking various postoperative outcomes, including prescription drug use. Although the development of perioperative eHealth or mobile health solutions for telemonitoring is still maturing [27], these technologies show promise as not only their implementation is feasible but they can also streamline clinical workflow and improve patient outcomes [28,29]. Web-based patient portals integrated with the EMR can improve patient satisfaction, enable more effective health care use [30], and improve outcomes such as glycemic control in patients with diabetes [31]. However, there are several barriers to successful implementation, as our experience with poor patient retention indicates (Figure 3). To improve patient engagement through an EMR portal, it is essential to avoid high attrition rates, which requires addressing the requirements of diverse patients, focusing on usability and functionality, and adopting implementation science approaches [32]; using apps can also have a positive impact [33]. Perioperative solutions must be designed with frequent and meaningful clinician and patient input and evaluated in large, robust clinical trials [27,29]. Particular attention is needed when developing and evaluating tools for vulnerable populations, such as patients with chronic pain issues and older patients, although a recent systematic review reported generally positive results from 7 studies on patients aged ≥65 years [34]. In contrast, our population was relatively younger, with a median age of 59 (IQR) (47-68) years. Furthermore, an evaluation of a patient-centric digital pain management app reported acceptable patient engagement and improved anxiety and pain catastrophizing in similarly aged patients who had experienced chronic pain of moderate to severe intensity for at least 3 months [33].

The lack of follow-up data prevented us from effectively evaluating or optimizing the risk stratification algorithm we implemented. The risk model was reasonably specific, based on in-hospital MME, but with poor sensitivity and a subsequent high false negative rate, as it failed to identify patients who may have benefited from the POQI-H platform. None of our 11 patient-reported preoperative risk factors had a significant adjusted OR for high in-hospital opioid use (>90 MME/day), in which the 95% CI range excluded 1 (Table 4). This indicates that by themselves, none of the risk factors would have predicted high postoperative opioid use in this cohort, although these are recognized risk factors. This contradicts the findings from our retrospective study in the same hospital, which found that a history of chronic pain and substance use disorder was associated with high postoperative opioid requirements [20]. The small sample sizes in both our retrospective and prospective cohorts may have limited our ability to detect these associations reliably in the chosen population. Alternatively, despite being evidence based [24], our selected threshold of >90 MME/day may not be optimal. Future work should explore other potentially self-reportable risk factors, such as open surgery, pain catastrophizing, or lack of planned regional anesthesia, as well as interactions between synergistic or antagonistic risk factors. Finally, data science approaches show promise in predicting postsurgical outcomes, with generally positive findings in a recent systematic review [35]. Such technology has been used to predict prolonged opioid use after orthopedic surgery [36] or estimate the risk of an adverse outcome within 30 days of an opioid dispensation [37]. These techniques may help refine local models, such as our algorithm, but we need more data at this stage.

Importantly, our platform was an amalgamation of various existing (or slightly adapted) technologies that lacked adequate workflow integration and did not adapt to varying clinical or patient needs to allow evaluation when there were any deviations from the predefined workflow. For example, we could not access clinically relevant long-term outcomes for many high-risk patients. Improving access to available administrative and clinical data could facilitate improved prediction performance using machine learning techniques [37].

We cannot report a fully realized solution due to a lack of integration with the provincial medication system and the reduced scope of the platform in light of the COVID-19 pandemic. However, the problems that we encountered and the lessons learned during our implementation can benefit other research, specifically clinical and industry teams endeavoring to build perioperative virtual care solutions to improve postoperative opioid use after discharge. Any work addressing this critical public health problem should ensure frequent engagement of patient and clinical partners, including co-design [38], to confirm that the design addresses patient and provider needs and delivers meaningful benefits to patient care and health care practice.

Next, when including a research component in health care system technical development and implementation, it is essential to ensure that research end points are integrated into project plans. This ensures that industry partners and clinical teams contribute to and approve evaluation plans so that the teams understand and support each other’s priorities. We also suggest including all partners in frequent data quality assessments and using an objective committee to oversee project activities, focusing on system-level goals while enabling each partner to achieve their respective objectives.

Given the likelihood that the requirement for virtual care solutions in the perioperative setting will grow, preparing for the transition to a long-term sustainable implementation is essential [39,40]. This should leverage experiences from stakeholders; focus on user experience; and ensure data are collected, validated, and delivered to the right people at the right time to improve the quality of care. Feedback is essential to a learning health system [41]: process metrics, patient trajectories, and benchmarking tools will enable clinicians to learn from their patients. PROMs and patient-reported experience measures [42] will be fundamental to improving the quality of care provided, focusing on patient-relevant outcomes rather than only system-relevant ones and enabling the personalization of care.

In addition to the implementation issues already discussed, we must acknowledge many limitations in the data that we have presented. First, restrictions to hospital access due to the COVID-19 pandemic care considerations leading up to and during the pilot recruitment period likely caused significant delays. It also hampered effective engagement between patients, the research team, clinical teams, and industry partners and disrupted the opportunity to refine the software solution through further design iterations.

Second, it is unclear from our data how patients used the information provided through the platform. The qualitative results from a limited number of patients willing to be interviewed and clinicians suggest that some patients glimpsed the potential value of the tool. However, they did not use or benefit from the educational materials and saw the platform as a survey tool rather than a virtual care platform. This may have contributed to the observed attrition rate and lack of interest in participating in usability interviews. Further design iterations were needed to respond to end user concerns and improve engagement in the platform. The lack of long-term follow-up was further compounded by technical issues and the lack of completed PROM survey data from patients. To prevent this from happening in the future, it may be better to engage and support patients’ needs through a prospective approach that uses a near real-time data pipeline and integrated interfaces directly into workflows at the point of care. The lack of bidirectional EMR integration is a limitation of our implementation. It likely contributed to our high attrition rates and compromised the quality of the data we could report on. As discussed, improving patient engagement through an EMR portal requires a more robust implementation approach than we could apply here.

Third, the primary aim of the algorithm to identify persistent postoperative opioid requirements could not be determined without access to prescription data to verify dispensed medications after discharge. Gaining such access using patient-directed or authorized access through the British Columbia Health Gateway was a project goal, and implementation was explored. However, it was found to be impossible due to provincial policy constraints. Hence, we cannot know whether the intervention impacted prolonged opioid use after surgery. Future studies should explicitly include long-term follow-up but may have to augment it with self-reports to capture the difference between dispensed and taken medications.

Finally, this analysis is limited due to a small sample size from a single center (including only 24, 11.9% of the 201 patients who used opioids >90 MME/day) and missing follow-up outcomes from many patients designated as high risk for significant postsurgical pain and opioid use. This is partly due to low engagement during the COVID-19 pandemic and challenges in achieving the project’s objectives within a limited funding period. Similarly, we planned to recruit 10 patients from the POQI-L group, 10 from the POQI-H group, and 5 clinicians to participate in semistructured interviews. However, we only obtained feedback from 3 patients (2 POQI-L users and 1 POQI-H user) and 4 clinicians. A broader sample would have provided more insight into the shortcomings and potential benefits of the system and should be built into any future evaluation.

Again, this final limitation was, at least in part, due to the COVID-19 pandemic. On the other hand, the COVID-19 pandemic created a greater motivation for developing and implementing systems that support virtual care through the perioperative process. This may be particularly relevant in a hospital such as St. Paul’s Hospital, a tertiary care academic hospital with patients from all over British Columbia, a geographically vast Canadian province with a widely distributed population. Finally, pain management requires multidisciplinary care that may not be available in rural communities. A well-designed platform could fill this gap and enable patients to benefit from personalized risk prediction and virtual prehabilitation while overcoming potential resource constraints.

Our POQI platform categorized patients who underwent colorectal surgery into high-risk or low-risk groups for significant postoperative pain and opioid use, using a pragmatic risk prediction algorithm. The algorithm’s performance was reasonably specific but not sensitive in predicting in-hospital opioid requirements. However, a significant loss in follow-up with postdischarge surveys suggested shortcomings in the design and implementation of the platform, which may have been improved with additional development work and the opportunity to engage patients more comprehensively. Important lessons learned during implementation included the early and frequent engagement of patients and clinical partners in the design and evaluation process. Finally, POQI platform users appreciated its potential impact on reducing opioid exposure, streamlining perioperative care, and improving patient outcomes, suggesting a redesign and evaluation before wider implementation is desirable.