Clinical Trials and Protocols in Perioperative Medicine

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Years in this theme: All years 2026 2025

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Articles published in this theme: 31 (scroll down to load remaining articles)

2026

Red 3D printed heart character with TENSINTEST label on hand

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Renin Kinetics and Hemodynamic Response During Treatment of Vasoplegic Shock With Angiotensin II (TENSINTEST): Protocol for a Multicenter Observational Study

Andreja Möller Petrun, Katarina Barbara Bajec, Lakhmir Chawla, Jan Zmazek, Andrej Markota

JMIR Res Protoc 2026 (Nov 09); 15:e102437

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Doctor reassures concerned senior man about joint pain in clinic

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Neoadjuvant Apalutamide With or Without Abiraterone Acetate Plus Prednisone and Gonadotropin-Releasing Hormone Agonist Prior to Nerve-Sparing Radical Prostatectomy in High-Risk Prostate Cancer: Protocol for a Randomized Phase 2 Trial

Anthony Y Zhang, Mark N Stein, Saum Ghodoussipour, Isaac Y Kim

JMIR Res Protoc 2026 (Nov 03); 15:e97886

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$Optometrist using an auto refractometer to examine a patient's eyes$

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Corneal Astigmatism Outcomes After Simultaneous Pterygium Excision Using The Bare Sclera Technique and Manual Small Incision Cataract Surgery: Protocol for a Prospective Single-Arm Pre-Post Interventional Cohort Study

Akshaya Tandle, Kanchan Selukar

JMIR Res Protoc 2026 (Sep 23); 15:e96749

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Physical therapist examining a patient's knee with a foam roller nearby

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Inspiratory Muscle Training Before Total Joint Arthroplasty to Improve Postoperative Outcomes: Protocol for a Randomized Controlled Trial

Barbara K Smith, Julie Shaner, Adam Gitlin, William Meier, Sabrina Wang, Maribel Ciampitti, Tatiana Elias-Grajeda, Ushna Khan, Johnny Washington, Michael Freidl, Stefan Braunecker

JMIR Res Protoc 2026 (Sep 11); 15:e103290

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Man in hat lighting a cigarette with a lighter

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Contingency Management for Veteran Smokers Undergoing Elective Major Surgery: Protocol and Rationale for a Pilot Randomized Controlled Trial

Christy Yim-Fan Wong, Ellen Herbst, Elliott Chaney, Theodore Fetterling, Isaac A Mirzadegan, Phiroz E Tarapore, Benjamin Emmert-Aronson, Gabriela K Khazanov, Katherine J Hoggatt, Madeline Martinez Rivas, Sadaf Dabiri, Jayabhargav Annam, Julia M Harris, Lauren Paver Thompson, Brian Borsari

JMIR Res Protoc 2026 (Sep 10); 15:e97779

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Plus-size woman exercises with dumbbells on a fitness ball at home

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Physical and Psychological Effects of Home-Based vs Face-to-Face Prehabilitation in Individuals With Severe Obesity Awaiting Bariatric and Metabolic Surgery: Protocol for a Randomized Controlled Trial

Darlan Laurício Matte, Guilherme Torres Vilarino, Alexandro Andrade, Ananda Quaresma Nascimento

JMIR Res Protoc 2026 (Aug 28); 15:e87053

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Physical therapist shows patient home exercise program on tablet during consultation

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A Coordinated Approach to Perioperative Rehabilitation to Enhance Outcomes in Melanoma: Protocol for the CARE-Melanoma Pilot Randomized Controlled Trial

Jenna Smith-Turchyn, Jordon L Hvizd, Valerie Francescutti

JMIR Res Protoc 2026 (Aug 21); 15:e90946

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Yoga sequence: Sun Salutation A (Surya Namaskar A) poses for beginners.

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Auricular Acupressure for Perioperative Anxiety and Pain in Therapeutic Breast Surgery: Protocol for a Randomized Clinical Trial

Mirela Bilc, Eva Beiner, Johanna Triana, Irene Rubio Rodríguez, Anja Birmanac-Pflüger, Holger Cramer, Marcela Winkler

JMIR Res Protoc 2026 (Aug 21); 15:e97469

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Medical team monitors patient vitals on screens in ICU and remote monitoring center.

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Evaluating Telemedical Supervision for Critical Anesthesia Scenarios: Randomized Controlled Simulation Study

Jonas Roth, Verena Voigt, Michael Schauwinhold, Andreas Follmann, Michael Czaplik

JMIR Med Inform 2026 (Aug 18); 14:e88056

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Nurse adjusts oxygen nasal cannula on smiling patient in hospital room.

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Study of High-Velocity Nasal Insufflation vs Noninvasive Positive Pressure Ventilation for Emergency Type 2 Respiratory Failure: Protocol for a Noninferiority Randomized Controlled Trial

Mui Teng Chua, Darius Shaw Teng Pan, Alexander Jet Yue Ng, Crystal Harn Wei Soh, Win Sen Kuan

JMIR Res Protoc 2026 (Aug 14); 15:e93391

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Surgeons in blue scrubs and masks perform a medical procedure under bright operating room lights.

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Navigation System–Assisted vs Freehand Cannulated Screw Fixation for Femoral Neck Fractures: Protocol for a Multicenter Randomized Controlled Trial

Meng Li, Dake Tong, Meng Cheng, Jiantao Li, Fang Ji, Wei Zhang

JMIR Res Protoc 2026 (Jun 23); 15:e88180

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Physical therapist applying TENS unit pads to a patient's upper back

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Comparing 2-Hz and 100-Hz Electroacupuncture for Postoperative Musculoskeletal Pain: Protocol for a 2 × 2 Prospective Randomized Crossover Trial

Jeong Hwan Park, Hyeong Joon Jun, Young-Eun Kim, Sanghun Lee, Daehyeok Kim, Sunmi Choi

JMIR Res Protoc 2026 (Jun 16); 15:e91706

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Doctor discusses medical results with a patient wearing a headscarf.

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Safety and Efficacy of Neoadjuvant Therapy in Cholangiocarcinoma: Protocol for a Systematic Review and Meta-Analysis

Saikat Mandal, Arkadeep Dhali, Manideepa Maji, Suresh Vasan Venkatachalapathy, Amardeep Khanna, Dhanwant Gomez, Arvind Arora, Guruprasad Aithal

JMIR Res Protoc 2026 (Jun 10); 15:e84912

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Doctor discusses supplements with patient, holding a bottle of pills.

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Bowel Stimulation Before Loop Ileostomy Closure Using Probiotics: Study Protocol for a Randomized Controlled Trial at a Single Center

Kyeong Eui Kim, Sung Uk Bae, Seong Kyu Baek, Woon Kyung Jeong

JMIR Res Protoc 2026 (Jun 04); 15:e87422

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Nurse holding patient's hand in hospital room with medical monitors.

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Piloting a Pragmatic Randomized Controlled Trial on the Effects of Integrated Psychosocial Care in Intensive Care Units (Phase B of the Integrated Psychosocial Care–Pilot Project): Protocol for a Feasibility Study

Heike Heytens, Simone Korger, Sophie Felicitas Nickel, Wencke Schindler, Melanie Elgner, Kader Aysu Şahin, Gironimo Krieg, Katrin Schürmann, Julianna Gehrig, Lorena Brenner, Marius Binneböse, Matthias Rose, Harald Gündel, Florian Junne, Christian Apfelbacher

JMIR Res Protoc 2026 (Jun 01); 15:e77490

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Patient using VR headset in hospital bed with doctor taking notes

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Virtual Reality for Preoperative Anxiety in Patients Undergoing Odontectomy Under General Anesthesia: Protocol for a Randomized Controlled Trial

Saptiadi Oktora, Harmas Yazid Yusuf, Eriska Riyanti, Firdaus Hariri

JMIR Res Protoc 2026 (May 26); 15:e94535

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Elderly woman in blue hospital gown sitting on medical examination table

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AI-Supported, Integrative Prediction of Postoperative Delirium: Protocol for the CONFUSED Study

Katharina Rump, Hartmuth Nowak, Martin Eisenacher, Samuel Busch, Britta Westhus, Matthias Unterberg, Sara Sordon, Lars Palmowski, Andrea Witowski, Malte Bayer, Thilo Bracht, Dominik Ziehe, Michael Adamzik, Tim Rahmel, Björn Koos, Lars Bergmann, Barbara Sitek

JMIR Res Protoc 2026 (May 25); 15:e87020

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Surgeons in blue scrubs and masks performing a delicate operation in a brightly lit operating room.

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Intercostal Cryoanalgesia Versus Thoracic Epidural Analgesia for Postoperative Pain Control After Thoracic Surgery: Study Protocol for a Randomized Clinical Trial

André Miotto, Juliana P Franceschini, Maria Luiza de Paula Pereira, Ernesto Evangelista Neto, João Aléssio Juliano Perfeito, Isabella Correia da Rocha, Maria Luiza Campos Ferreira, Suéllen Battaglini Rolando

JMIR Res Protoc 2026 (May 19); 15:e91837

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Elderly man experiencing virtual reality with a VR headset

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Immersive Virtual Reality for Pain and Relaxation in Older Adults Following Elective Inpatient Abdominal Surgery: Single-Arm Study Examining Feasibility and Acceptability

Christina Keny, Ujala Shafiq, Karl Lorenz, Marcia Russell, Heather Leutwyler, Laura M Wagner, Victoria Tang, Linda G Park

JMIR Perioper Med 2026 (Apr 17); 9:e81791

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Surgical team in scrubs preparing for orthopedic surgery with instruments and equipment

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Comparison of Uncemented and Hybrid Hip Arthroplasty: Protocol for a Brazilian Randomized Controlled Trial

Bruno Gonçalves Schroder e Souza, Matheus Malta Vasconcelos, Nathália Lacerda Furtado, Marco Antônio Perígolo Magalhães, Valdeci Manoel de Oliveira, Carolina Tsen, Carlos Henrique Cavaglieri Silveira Silva, Luiz Guilherme Vidal Assad, Leonã Aparecido Homem do Amaral, Iasmim Sand Ferreira de Souza, Julia Machado Vieira, Isabella Dias Lacerda

JMIR Res Protoc 2026 (Mar 16); 15:e79721

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